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Max Ulbrich Profile Page
Max Ulbrich


Lab: Dr. Max Ulbrich
Department: Department of Internal Medicine IV
Address: BIOSS
Centre for Biological Signalling Studies
Schänzlestr. 18
79104 Freiburg
Phone: +49 761 203 97183
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster: YES
PhD positions available: YES
Research Area: Synthetic Biology and Signalling
Research Interests: Membrane protein assembly, single molecule imaging, superresolution, biophysics of receptors in neuroscience, immunology and signalling


Education & Training: 1993-1999: Study of Physics, Technical University Munich
1999-2003: PhD in Physics, Technical University Munich and Max-Planck-Institute for
Biochemistry, Martinsried
Employment & Experience: 2004-2009: Postdoctoral fellow in the laboratory of Ehud Isacoff, University of California,
2010-present: Junior-Professor at BIOSS and the Institute of Physiology, Albert-Ludwigs-
University Freiburg, Germany


Honors and Awards:

2004-2005 Postdoctoral Fellowship of the German Research Association (DFG)
2006-2008 Postdoctoral Fellowship of the American Heart Association (AHA)
2009 NIH Pathway to Independence Award (K99/R00)


Selected Publications:

Lan C, Stulz A, Barthes NPF, Lauw S, Salavei P, Jung M, Heerklotz H, Ulbrich MH. Designed membrane protein heterodimers and control of their affinity by binding domain and membrane linker properties. Nanoscale. 2021 Dec 16;13(48):20692-20702.  Abstract

Cechova K, Lan C, Macik M, Barthes NPF, Jung M, Ulbrich MH. Kappa but not delta or mu opioid receptors form homodimers at low membrane densities. Cell Mol Life Sci. 2021 Dec;78(23):7557-7568.  Abstract

Knoch H, Ulbrich MH, Mittag JJ, Buske J, Garidel P, Heerklotz H. Complex Micellization Behavior of the Polysorbates Tween 20 and Tween 80. Mol Pharm. 2021 Aug 2;18(8):3147-3157.  Abstract

Steinberg R, Origi A, Natriashvili A, Sarmah P, Licheva M, Walker PM, Kraft C, High S, Luirink J, Shi WQ, Helmstädter M, Ulbrich MH, Koch HG. Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle. PLoS Biol. 2020 Sep 30;18(9):e3000874.  Abstract

Chen C, Ulbrich MH. Zinc-Finger-Mediated Labeling Reveals the Stoichiometry of Membrane Proteins. ACS Nano. 2020 Apr 28;14(4):4134-4140. Abstract

Bender J, Bognar S, Camagna M, Donauer JAM, Eble JW, Emig R, Fischer S, Jesser R, Keilholz L, Kokotek DMU, Neumann J, Nicklaus S, Oude Weernink RRQPT, Stühn LG, Wössner N, Krämer SD, Schwenk P, Gensch N, Roth G, Ulbrich MH. Multiplexed antibody detection from blood sera by immobilization of in vitro expressed antigens and label-free readout via imaging reflectometric interferometry (iRIf). Biosens Bioelectron. 2018 Sep 15;115:97-103.  Abstract

Enderle B, Sheerin DJ, Paik I, Kathare PK, Schwenk P, Klose C, Ulbrich MH, Huq E, Hiltbrunner A. PCH1 and PCHL promote photomorphogenesis in plants by controlling phytochrome B dark reversion. Nat Commun. 2017 Dec 20;8(1):2221. Abstract

Bartoi T, Augustinowski K, Polleichtner G, Gründer S, Ulbrich MH. Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8281-6.  Abstract

Arant RJ, Ulbrich MH. Deciphering the subunit composition of multimeric proteins by counting photobleaching steps. Chemphyschem. 2014 Mar 17;15(4):600-5. Abstract

Ulbrich MH, Isacoff EY. Rules of engagement for NMDA receptor subunits. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14163-8.  Abstract

Ulbrich MH, Isacoff EY. Subunit counting in membrane-bound proteins. Nat Methods. 2007 Apr;4(4):319-21.  Abstract

SGBM PhD students

SGBM PhD students:

Klara Lesch (since September 2019)

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