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Michael Quante

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Lab: Prof. Dr. Michael Quante
Department: Klinik für Innere Medizin II, Gastrointestinale Onkologie
University Medical Center
Address: Hugstetter Str 55
79106 Freiburg
Phone: +49 761 270 32766
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.uniklinik-freiburg.de/medizin2/forschung/experimentelle-forschung/ag-quanteheeg.html
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: In our laboratory we are working on the pathogenesis of Barrett's esophagus (BE) and the resulting adenocarcinoma of the esophagus (EAC), a disease with a high a high potential for new preventive surveillance strategies. We have generated the only genetic mouse model for this disease to date and have demonstrated that the microenvironment plays a significant role in the pathogenesis of this disease and that the origin of BE and EAC is located in the stomach and not in the esophagus as previously thought. This represents a change understanding of this disease and initiated a paradigm shift with implications for diagnostics, monitoring strategies, and therapy. We are now focusing on the role of stem cells and cancer initiating cells for carcinogenesis and prevention and work on translation our findings into clinical routine for cancer screening and therapy

CV

Education & Training: 2018: Facharzt für Gastroenterologie
2014: Facharzt für Innere Medizin
2005: MD, School of Medicine, Heinrich Heine Universität, Düsseldorf, Germany
2001-2004: School of Medicine, Albert-Ludwigs Universität Freiburg, Germany
1999-2001: School of Medicine, Westfälische Wilhelms Universität Münster, Germany
Employment & Experience: Since 2021: Head of Interdisciplinary Center of Gastrointestinal Cancer (UKF)
Since 2021: Co-Director Comprehensive Cancer Centre Freiburg, Germany
Since 2020: W3 Professorship Gastrointestinal Oncology, University of Freiburg, Germany
2016-2020: Head of Interdisciplinary Oncology Clinic, Roman Herzog Cancer Center, Technical University of Munich, Germany
2015-2020: Consultant Gastrointestinal Oncology, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany
2011-2014: Clinical Fellow
2010-2011: Associate Research Scientist, Columbia University Medical Center, New York, USA
2008-2010: Postdoctoral Fellow, Columbia University Medical Center, New York, USA
2006-2008: Clinical Fellow, Medizinische Klinik II, Universität Bonn, Germany

Publications

Selected Publications:

Kunze B, Wein F, Fang HY, Anand A, Baumeister T, Strangmann J, Gerland S, Ingermann J, Münch NS, Wiethaler M, Sahm V, Hidalgo-Sastre A, Lange S, Lightdale CJ, Bokhari A, Falk GW, Friedman RA, Ginsberg GG, Iyer PG, Jin Z, Nakagawa H, Shawber CJ, Nguyen T, Raab WJ, Dalerba P, Rustgi AK, Sepulveda AR, Wang KK, Schmid RM, Wang TC, Abrams JA, Quante M. Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma. Gastroenterology. 2020 Aug;159(2):575-590.  Abstract

Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M. High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome. Gastroenterology. 2019 Aug;157(2):492-506.e2.  Abstract

Wiethaler M, Slotta-Huspenina J, Brandtner A, Horstmann J, Wein F, Baumeister T, Radani N, Gerland S, Anand A, Lange S, Schmidt M, Janssen KP, Conrad A, Johannes W, Strauch K, Quante AS, Linkohr B, Kuhn KA, Blaser R, Lehmann A, Kohlmayer F, Weichert W, Schmid RM, Becker KF, Quante M. BarrettNET-a prospective registry for risk estimation of patients with Barrett's esophagus to progress to adenocarcinoma. Dis Esophagus. 2019 Aug 1;32(8):doz024.  Abstract

Quante M, Graham TA, Jansen M. Insights Into the Pathophysiology of Esophageal Adenocarcinoma. Gastroenterology. 2018 Jan;154(2):406-420.  Abstract

Schellnegger R, Quante A, Rospleszcz S, Schernhammer M, Höhl B, Tobiasch M, Pastula A, Brandtner A, Abrams JA, Strauch K, Schmid RM, Vieth M, Wang TC, Quante M. Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma. Cancer Prev Res (Phila). 2017 Jan;10(1):55-66.  Abstract

Fang HY, Münch NS, Schottelius M, Ingermann J, Liu H, Schauer M, Stangl S, Multhoff G, Steiger K, Gerngroß C, Jesinghaus M, Weichert W, Kühl AA, Sepulveda AR, Wester HJ, Wang TC, Quante M. CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma. Clin Cancer Res. 2018 Mar 1;24(5):1048-1061.  Abstract

Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC. Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest. 2014 Mar;124(3):1283-95.  Abstract

Quante M, Bhagat G, Abrams JA, Marache F, Good P, Lee MD, Lee Y, Friedman R, Asfaha S, Dubeykovskaya Z, Mahmood U, Figueiredo JL, Kitajewski J, Shawber C, Lightdale CJ, Rustgi AK, Wang TC. Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell. 2012 Jan 17;21(1):36-51.  Abstract

Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, Friedman R, Varro A, Tycko B, Wang TC. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 2011 Feb 15;19(2):257-72.  Abstract

Quante M, Marrache F, Goldenring JR, Wang TC. TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology. 2010 Dec;139(6):2018-2027.e2.  Abstract

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