Claudine Kraft

Claudine Kraft Profile Page

Contact

Lab:	Prof. Dr. Claudine Kraft
Department:	Institute of Biochemistry and Molecular Biology
Address:	Stefan-Meier-Str. 17 79104 Freiburg
Phone:	+49 761 203 5221
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.kraftlab.org/
PhD positions available:	NO
Research Area:	Protein Structure and Function
Research Interests:	Our group aims at understanding how the molecular machinery of autophagy, the cellular waste disposal system, works. We use biochemical, cell biological and genetic approaches in budding yeast and mammalian cells to dissect the molecular mechanisms underlying autophagosome formation, transport and fusion with the lytic compartment.

CV

Education & Training:	2001-2005 PhD thesis, IMP Vienna, Austria; Lab of Jan-Michael Peters 2000-2001 Diploma thesis, University of Manchester, UK; Lab of Steve High 1997-2001 Diploma in Molecular Biology, University of Basel, Switzerland
Employment & Experience:	since 2017 Professor (W3), University of Freiburg, Germany 2011-2017 Group leader, MFPL University of Vienna, Austria 2006-2011 Postdoc, ETH Zürich, Switzerland; Lab of Matthias Peter

Honors

Honors and Awards:

2018 ERC Consolidator grant
2017 H2020 Marie Curie Innovative Training Network "DRIVE"
2016 EMBO small grant
2015 Member of the COST action "Transautophagy" (CA15138)
2015 FWF stand alone grant
2014 EMBO Young Investigator Award
2013 FWF stand alone grant
2012 AcademiaNet member (nominated by the SNSF)
2011 WWTF startup grant “Vienna Research Groups for Young Investigators”
2008 Marie-Heim Vögtlin postdoc fellowship (Swiss National Science
Foundation, 31 months)
2006 EMBO long-term fellowship
2005 PhD award of the Campus Vienna Biocenter

Publications

Selected Publications:

Torggler R, Papinski D, Kraft C. Assays to Monitor Autophagy in Saccharomyces cerevisiae. Cells. 2017 Jul 13;6(3). Abstract

Torggler R, Papinski D, Brach T, Bas L, Schuschnig M, Pfaffenwimmer T, Rohringer S, Matzhold T, Schweida D, Brezovich A, Kraft C. Two Independent Pathways within Selective Autophagy Converge to Activate Atg1 Kinase at the Vacuole. Mol Cell. 2016 Oct 20;64(2):221-235. Abstract

Papinski D, Kraft C. Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex. J Mol Biol. 2016 May 8;428(9 Pt A):1725-41. Abstract

Brezovich A, Schuschnig M, Ammerer G, Kraft C. An in vivo detection system for transient and low-abundant protein interactions and their kinetics in budding yeast. Yeast. 2015 Mar;32(3):355-65. Abstract

Pfaffenwimmer T, Reiter W, Brach T, Nogellova V, Papinski D, Schuschnig M, Abert C, Ammerer G, Martens S, Kraft C. Hrr25 kinase promotes selective autophagy by phosphorylating the cargo receptor Atg19. EMBO Rep. 2014 Aug;15(8):862-70. Abstract

Papinski D, Schuschnig M, Reiter W, Wilhelm L, Barnes CA, Maiolica A, Hansmann I, Pfaffenwimmer T, Kijanska M, Stoffel I, Lee SS, Brezovich A, Lou JH, Turk BE, Aebersold R, Ammerer G, Peter M, Kraft C. Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Mol Cell. 2014 Feb 6;53(3):471-83. Abstract

Kraft C*, Kijanska M, Kalie E, Siergiejuk E, Lee SS, Semplicio G, Stoffel I, Brezovich A, Verma M, Hansmann I, Ammerer G, Hofmann K, Tooze S, Peter M*. Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy. EMBO J. 2012 Sep 12;31(18):3691-703. (*corresponding authors). Abstract

Kraft C*, Martens S*. Mechanisms and regulation of autophagosome formation. Curr Opin Cell Biol. 2012 Aug;24(4):496-501. (*corresponding authors). Abstract

Kijanska M, Dohnal I, Reiter W, Kaspar S, Stoffel I, Ammerer G, Kraft C*, Peter M*. Activation of Atg1 kinase in autophagy by regulated phosphorylation. Autophagy. 2010 Nov;6(8):1168-78. (*corresponding authors). Abstract

Kraft C*, Deplazes A, Sohrmann M, Peter M*. Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nat Cell Biol. 2008 May;10(5):602-10. (*corresponding authors). Abstract

SGBM PhD students

SGBM PhD students:

Anuradha Bhattacharya (since October 2018)

Christopher Eickhorst (since September 2018)